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'Depressing,' 'manipulative' portrayals damage hunger work in Africa ...

Oxfam UK

Oxfam UK launched a new advertising campaign this week seeking to shift the focus to progress in Africa and away from 'depressing' images fostered by Live Aid and other well-intentioned efforts.

By M. Alex Johnson, NBC News

Twenty-seven years after Live Aid viscerally brought Africa's famine and poverty home to billions worldwide, the head of a major international charity?warned Wednesday that the "depressing" stereotypes left in its wake were counterproductive and risked driving help away.

The British arm of Oxfam International called images of starving babies and other familiar depictions of Africa over the last quarter-century "manipulative and hopeless," desensitizing potential donors and leading them to the conclusion that conditions in the developing world can never improve.?

Oxfam launched a new advertising campaign this week celebrating Africa's natural beauty and progress toward alleviating hunger. Called "Food for All," the campaign features images of lush green scenery, wildlife and thriving African food markets.

The campaign's tagline: "Let's Make Africa Famous for Its Epic Landscapes, Not Hunger."

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Dame Barbara Stocking, the British charity's chief executive, said in a posting on Oxfam's website that "we've come a long way since the 1980s and Band Aid's 'Do They Know It's Christmas?'"

But "we need to shrug off the old stereotypes and celebrate the continent's diversity and complexity," she contended.

Band Aid, the musical charity supergroup formed in 1984 by Bob Geldof and Midge Ure, recorded "Do They Know It's Christmas?" in response to the crippling famine in Ethiopia. In 2004, on the song's 20th-anniversary re-release, the World Development Movement condemned it as "patronizing, false and out of date."

Geldof and Ure organized the landmark fundraising concert Live Aid in 1985, bringing dire conditions in Africa front and center to people around the world.

"'Patronizing' isn't the word" to describe the message fostered by Band Aid and other well-intentioned campaigns, Stocking said Wednesday in an interview on Sky News. "It's just this negativity. ...

"In order for people to understand what's happening in Africa, we've also got to tell the good stories, and there has been good news in Africa," said Stocking, who is retiring in the new year after serving with the charity since 2001.?

"Otherwise, people just feel put off and (believe) there's nothing that can be done about Africa," she said. "And that's the big worry for us ? that people feel it's all hopeless, when it clearly isn't."

World Bank statistics indicate that the world's heaviest concentration of malnutrition remains in Africa, afflicting as many as 15 percent of all children under 5 in some countries in the southern and eastern regions. And in June, the U.N. Children's Fund reported that 1.5 million children were at imminent risk of starvation in the western half of the continent.

Watch World News videos on NBCNews.com

But while acknowledging that international aid has made few if any inroads on hunger, Oxfam said in a report this month that countries south of the Sahara Desert had made "one of the most remarkable turnarounds in development ... in the last decade." It called the 22 years from 1990 to 2011 an "African renaissance."

Oxfam: Africa is wide awake but still hungry (.pdf)

"Economies have been growing even in the face of economic and financial instability elsewhere in the world, poverty has fallen and child mortality has dropped considerably, among the most visible indicators of progress," the report said.

The real story, Stocking said Wednesday, is that "aid money is really working."

But in the end, she said, "we don't want to have to give aid money to Africa. We want economic development, enterprise ? that's what we're really aiming to do."

More world stories from NBC News:

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Source: http://worldnews.nbcnews.com/_news/2012/12/26/16168054-depressing-manipulative-portrayals-damage-hunger-work-in-africa-oxfam-complains?lite

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Mimicking a natural defense against malaria to develop new treatments

Dec. 27, 2012 ? One of the world's most devastating diseases is malaria, responsible for at least a million deaths annually, despite global efforts to combat it. Researchers from the Perelman School of Medicine at the University of Pennsylvania, working with collaborators from Drexel University, The Children's Hospital of Philadelphia, and Johns Hopkins University, have identified a protein in human blood platelets that points to a powerful new weapon against the disease.

Their work was published in this months' issue of Cell Host and Microbe.

Malaria is caused by parasitic microorganisms of the Plasmodium genus, which infect red blood cells. Recent research at other universities showed that blood platelets can bind to infected red blood cells and kill the parasite, but the exact mechanism was unclear. The investigators on the Cell Host and Microbe paper hypothesized that it might involve host defense peptides (HDP) secreted by the platelets.

"We eventually found that a single protein secreted when platelets are activated called human platelet factor 4 [hPF4] actually kills parasites that are inside red cells without harming the red cell itself," explains senior author Doron Greenbaum, PhD, assistant professor of Pharmacology, whose team studies innovative ways to fight malaria. The hPF4 targets a specific organelle of the Plasmodium falciparum parasite called the digestive vacuole, which essentially serves as its "stomach" for the digestion of hemoglobin. The investigators found that hPF4 destroys the vacuole with a deadly speed of minutes or even seconds, killing the parasite without affecting the host cell.

While host defense peptides appear to be attractive therapeutic agents, the expense of manufacturing this protein lessens its potential impact on the treatment of malaria. Greenbaum and colleagues set out to discover whether synthetic molecules mimicking the structure of HDPs could have similar beneficial effects against the Plasmodium parasite. After screening approximately 2000 small molecule HDP mimics (smHDPs) developed by biotech company PolyMedix, Inc. of Radnor, PA, Greenbaum and his team found that "all of the best hits had the same mechanism of action against Plasmodium parasites."

Like the natural hPF4 found in platelets, the most effective smHDPs tested targeted only infected red blood cells, attacking and destroying the parasite in exactly the same way, but with even greater potency and speed. "The smHDPs get into infected red cells and lyse or basically destroy the digestive vacuole or stomach of the parasite more rapidly than the hPF4 protein," Greenbaum notes. "The protein from platelets is about 25 times less potent, but the surprising thing is they act with the same mechanism. With ease, within seconds, they destroy the vacuole of the parasite."

Greenbaum's team settled on two compounds, PMX1207 and PMX207, for testing in mouse models of malaria. Both compounds significantly decreased parasitic growth and greatly improved survival rates, providing further confirmation of the potential of smHDPs as antimalarial agents. The work, Greenbaum says, shows that "we can translate a natural arm of the innate immune system in platelets to drug-like small molecules that we are honing to become potent, selective, potentially less toxic, and cheaper to make as an antimalarial."

Aside from their great effectiveness, smHDPs may have several other advantages over other antimalarial therapies. As Plasmodium inevitably adapts and becomes resistant to a particular drug therapy, the efficacy of that treatment decreases and survival rates drop. By mimicking the body's own natural defenses, the new HDP-centered approach could avoid that pitfall. "Certainly with malaria we've had a lot of problems in the last 20 years with resistance," Greenbaum explains. "One of the unique features of the synthetic HDPs is that studies show that pathogens have a difficult time generating resistance to them, because they attack membranes, not proteins. So they might be intrinsically more difficult to become resistant against."

Although Greenbaum's team focused mostly on the chronic red-blood-cell stage of malaria, their HDP-mimic also shows promise against other stages of the disease. "We think that the mimics would be useful as a transmission-blocking therapeutic," Greenbaum says. "In other words, you prevent transmission from human to mosquito and therefore back to human again. We have positive data for those two stages. It's becoming increasingly more important in antimalarial drug development that people think more and more about multistage inhibition."

The next step for Greenbaum's team is to further hone the selectivity and potency of the smHDP compounds, while developing them into drugs that can be orally administered. As Greenbaum explains, practical antimalarials need to be "taken as pills rather than having to be used intravenously, which is not going to be appropriate for treatment in endemic countries, especially in more rural environments."

Co-authors are Melissa S. Love, Melanie G. Millholland, Satish Mishra, Swapnil Kulkarni, Katie B. Freeman, Wenxi Pan, Robert W. Kavash, Michael J. Costanzo, Hyunil Jo, Thomas M. Daly, Dewight R. Williams, M. Anna Kowalska, Lawrence W. Bergman, Mortimer Poncz, William F. DeGrado, Photini Sinnis, and Richard W. Scott.

The research was funded by the National Institutes of Health (R44 AI090762-0; NIHT32GM08076; NIHT32AI007532; R01 AI056840); a Penn TAPITMAT Pilot Program; the Penn Genome Frontiers Institute; and a Gates Grand Challenges Exploration Program.

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Story Source:

The above story is reprinted from materials provided by Perelman School of Medicine at the University of Pennsylvania.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Melissa?S. Love, Melanie?G. Millholland, Satish Mishra, Swapnil Kulkarni, Katie?B. Freeman, Wenxi Pan, Robert?W. Kavash, Michael?J. Costanzo, Hyunil Jo, Thomas?M. Daly, Dewight?R. Williams, M.?Anna Kowalska, Lawrence?W. Bergman, Mortimer Poncz, William?F. DeGrado, Photini Sinnis, Richard?W. Scott, Doron?C. Greenbaum. Platelet Factor 4 Activity against P.?falciparum and Its Translation to Nonpeptidic Mimics as Antimalarials. Cell Host & Microbe, 2012; 12 (6): 815 DOI: 10.1016/j.chom.2012.10.017

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/Az0RV2Wy5vY/121227130208.htm

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PR Newswire's Business Technology Round-up, 27 December 2012

LONDON, December 27, 2012 /PRNewswire/ ?

?Swapviva? app launched, new LG laser TV to hit the market and NQ Mobile celebrates double-entry in apps shortlist

Smartphone?and tablet users looking for somewhere to list any of their unwanted Christmas presents for sale have a brand new alternative to the likes of Craigslist and eBay.?Swapviva, an?app?launched recently in Seattle, lets members of its service sell or even trade items for other goods or services using the platform.

Photos and descriptions can be uploaded simply, and members will be able to offer their own unwanted items in exchange. The?app, which was co-founded by brothers Mihai and Alex Draghici , is inspired by the television show?Barter Kings?and offers users a ?clean app interface? for keeping their incoming and outgoing trades and transactions organised.

In another launch,?LG Electronics?announced the arrival of its 100-inch (diagonal) class Laser TV, which is to see its first public demonstration at next month?s 2013 International CES.

The LG ?HECTO? Laser TV, which boasts both Digital and Smart TV capabilities, creates a top-level home theatre experience using an innovative projector system which requires the lens to be placed a mere two feet away from the screen, either on the floor or ceiling. The 1080p Full HD resolution combined with a 1,000,000:1 dynamic contrast ratio is just as clear in lighter rooms as it is in darkened ones.

The Laser TV also boasts integration with premium content providers such as Netflix and YouTube thanks to its built-in Wi-Fi, as well as smart connectivity that allows users to stream content from compatible devices.

Elsewhere in relation to CES 2013,?a leading global provider?of mobile Internet services has seen two of its products named in the top 25 apps at the Mobile Apps Showdown for the exhibition.

The two apps, NQ Mobile Security and NQ Family Guardian, are both produced by NQ Mobile and offer what the company?s Chief Product Officer, Gavin Kim , describes as ?cutting edge security solutions and protection for families?.

NQ Mobile Security provides protection for mobile devices against viruses, malicious URLs and other potential security risks, and is described as having a 99 percent malware detection rate. NQ Family Guardian, on the other hand, carries a number of customisable features to filter, block and monitor activity on a child?s smartphone.

All 25 apps in the line-up of semifinalists are selected by an expert panel with extensive knowledge in reviewing similar products.?

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Transform Your Article Marketing Success With These Top Tips ...

Education in article marketing is key. There is a lot of available information you can read, however not all of it pertains to your particular situation. The below article provides lots of excellent advice on article marketing that is certain to be effective for you.

When you are done with your article, it?s important that you look it over for errors; mistakes can affect your credibility. Check over everything twice just to be sure everything is spelled right and that correct grammar is being used. In order to make the most money possible, you have to write well.

Constantly promote your affiliate business whenever you can. Identify problems and find products that address them. This will help create demand around your writing, which can improve your visibility. Make these activities second nature, and you will find that growing your business requires less effort over time and brings a higher success rate.

Put a question in your article titles. Our brains love the challenge and mystery of questions. Using a question allows you to grab your readers? frontal lobe and stops them to make them read your article. Follow the question with content that is equally as captivating.

Try using numbers in the titles of your articles if they relate to the content. Titles that have numbers in them will help to draw in people which will result in more viewers. To see which numbers seem to hit home, watch which articles get the most visitors.

Tools can be used to increase your visibility. There are a lot out there that can send in your article to a variety of directories, more than you could do on your own. Most of these tools cost a fee, but there are a select few that operate for free. Seek these out, as they are a cheap way to gain readership.

Write in a language you feel comfortable with. Though you may be comfortable speaking a different language, avoid the temptation to use it for article marketing purposes. You could still end up with horrifying sentence structure. You will also have a different view of the world than foreign readers, and that could end up confusing them.

Write concise, direct articles. There is no point in writing articles full of fluff or filler that no one wants to read. 250 to about 500 words should be your limit. Be sure to keep it interesting so that your reader will finish reading the entire thing before they get bored and move on to another site.

When it comes to article marketing, you must write quality content. Fluff and nonsense is not acceptable and will only hurt you. If something needs further explanation, don?t be afraid of devoting the extra space; however be brutal when it comes time to trim away the excess. Don?t forget to proofread! Look for irrelevant sentences, spelling errors and other potential pitfalls in your writing.

Any article you write to advertise your site should be entertaining to the reader. Always write in an informal style that?s friendly and warm. Introduce your technical information so everyone can understand if you want your complex articles to remain friendly. Avoid alienating readers by being boring.

Take full advantage of the opportunities of social media. Take advantage of your Facebook account or your Twitter account; they can be very good ways to attract new readers. All you need to do is post updates after each new article you write. You can also ask your followers to share your articles with their friends for an even higher boost in traffic.

There are many marketing ideas that are new and many that are standard practice. Take what you have learned here, and you will be an ?expert? in no time!

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About Kyle Haycock

Hello, I'm Kyle Haycock. I'm a former Staff Sergeant in the US Marines. I've married to my wonderful wife for almost 11 years and have two beautiful daughters (8 and 10 years old). I've been in business for myself for over six years and have been network marketing for two years. I am semi-retired now, but my dream is to make enough money for myself and for others that I can become a full-time philanthropist like Bill Gates. My true passion is teaching and believe that if we can teach youngsters properly while they're young that they can become productive and successful members of society (as they define it). With me making more money and inspiring others to do the same, I can gather a whole legion of people fighting for the same cause.

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Divorce-Proof Marriage: 10 Reasons I'm Sure We'll Never Split

By Amber Doty for YourTango.com

By now, you've probably heard the widely-touted statistic that the divorce rate in the U.S. is 50 percent. According to the Pew Research Center, though, the rate of divorce is on the decline (along with the rate of marriage). This success is likely due, in large part, to the fact that people are waiting longer than ever to walk down the aisle.

While I agree that stability is certainly important, I don't buy into the idea that age is a deciding factor in whether a marriage ends in divorce. It's not the case at all with my marriage.

My husband and I met and began dating when I was a teenager and were married in our early twenties. More than eight years later, I am as confident as I was on our wedding day that our marriage will last a lifetime. In fact, I would go so far to say our union is divorce-proof. Here are 10 reasons why.

1. We wanted a marriage, not a wedding. Recently, I had coffee with a friend going through a divorce after only two years of marriage. When I asked what happened, she replied without pause, "I wanted a wedding, not a marriage." She went on to explain that, after years of dating, getting married seemed like the next logical step in their relationship and the timing was right for them to fund the wedding of her dreams. From seating arrangements to color schemes and everything in between, there are many decisions to be made while planning a walk down the aisle. It can be easy to lose sight of the ultimate goal: to begin a lifelong relationship with the person you love. But the hard part isn't in saying "I do," it's in choosing to say it again and again for the rest of your life. For my husband and me, the focus was always on the morning after (and every other morning after that) instead of the "big day."

2. We didn't wait until after the wedding to tackle important issues. It can be awkward when you're dating to discuss things like the number and timing of children, personal approaches to finances, where you see yourself living down the road, or what religion your family will practice, but knowing the answers to these questions before you marry can mean the difference between a rocky start and a smooth transition into your new lives together. Everyone has their dealbreakers, but identifying ours before we gathered 100 of our closest friends and family members to pledge our lives together for all eternity cut down on surprises after they had all gone home. I am always shocked by the number of marriages that end in divorce because a couple never bothered to discuss their ideas for the future.

3. We put each other and our marriage first. Our children come second. I?ve written about it before here on YourTango. I love my children, but I am in love with my husband and prioritizing our relationship is good for our family as a whole.

4. When it comes to our relationship, our in-laws are outlawed. Mother-in-laws are at the center of many a sitcom and romantic comedy shenanigan -- and for good reason. They're notorious for causing marital strife both on-screen and off. That's why my husband and I have made it clear that while I can't control his mother's opinion on my cooking and he will never escape my mom's incessant nagging on the upkeep of our yard, their thoughts on our relationship are unwelcome. When we need advice or just to vent, we seek out the listening ear of a friend, not a family member.

5. Our bedroom is a child-free zone. Nothing kills the mood faster than reaching under the sheets mid-romp to dislodge an uncomfortable object that turns out to be a half-empty sippy cup.

6. We use our past to our advantage, not our detriment. My husband and I both come from divorced families, a fact that many studies agree puts couples at greater risk for divorce themselves. But history doesn't have to repeat itself. We talk openly, both together and with therapists, about what went wrong in our parents' marriages and how it affected our lives and our perception of matrimony.

7. We maintain common interests. One of the very first conversations my husband and I shared was a discussion of a book we had both recently read. It's dorky, but we're suckers for a good horror novel. While the differences in our personalities and our day-to-day are vast (he works long hours in law enforcement; I work from home as a freelance writer), we share reading material and talk about it regularly. A book club for two may not be the foundation on which our marriage is built, but it is a reminder of why we got together in the first place beyond the roles we have assumed since our relationship began.

8. We practice emotional self-regulation. In an article highlighting the skills every person should master before getting married, YourTango expert, Dr. Susan Heitler, emphasizes the importance of learning to control your emotions. You can remove nails driven into a board, but you can't undo the holes they create. The same is true for words said in the heat of the moment. Taking time to cool down instead of entering into a shouting match has been the difference between a marital spat and a major blow-up.

9. We give each other space. When I step out for a much needed day away from the house, I am confident my phone will not ring unless there is an emergency. Likewise, when he arrives home from work, I give him time to relax before handing off the childcare responsibilities. A little independence and time to ourselves is as vital to the health of our marriage as fostering a common bond.

10. We split the parenting duties equally. Nothing breeds resentment faster in a marriage than feeling like you are solely responsible for the diaper changing and late-night feedings. Since the day our first child was born my husband and I have adopted a 50/50 approach to parenting. "You get this one. I got the last one," is a frequently uttered phrase in our home. We also share the burden that being a parent can place on a career. There is no expectation that, as the woman, I will shoulder the responsibility of taking a day off when our children are ill. Nothing makes me feel more supported and secure in our relationship than knowing my husband and I are partners in parenthood.

Are you confident your marriage is divorce-proof? How do you maintain a healthy relationship with your spouse?

More Stories On YourTango:

Having So-So Sex? 6 Ways To Make It Mind-Blowing

Old News, New Research: Men Really Do Want To Marry Their Moms

Jessica Biel's Sexy Reason She Loves Life With Justin Timberlake

The Best Love Advice On YourTango

Affection: Does He Care?

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Source: http://www.huffingtonpost.com/2012/12/26/divorce-proof-marriage_n_2281150.html

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Apple patents a method to refine curved glass for displays and beyond

The curved screens of Samsung's Nexus S and Galaxy Nexus helped them stand out in the smartphone crowd, but it's clearer than ever that the company doesn't have a lock on the idea. Apple is exploring the concept as well: it just received a patent for a technique that molds thin glass into bent or curved shapes without a drawn-out process or using risky chemicals. By having alignment tools shift along with hotter temperatures during a glass slumping process, where the material shapes itself around a mold, Apple can bend glass without any interference -- leading to curvy surfaces that are both quicker to make and higher quality. A patent doesn't mean that we'll see a curved iPhone in the immediate future, though. Apple leaves its options open and suggests that anything from mice to TVs could be candidates, should the company take action at all. If the patent ever applies to real-world products, however, we'll have an inkling as to how the bendy shapes came to be.

Filed under: Cellphones, Displays, Peripherals, Apple

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Source: USPTO

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/comE7-H6_W4/

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